Killer Instinct may refer to:
- Killer Instinct series, the titular fighting game franchise created by Rare since 1994, releasing a number of related media.
- Killer Instinct (1994 video game), the first installment in the series, developed by Rare and published by Midway and Nintendo.
- Killer Instinct (2013 video game), the third installment and the series' reboot, developed by Double Helix Games and later Iron Galaxy Studios.
- Killer Instinct Comics, the official comics of the series released within the year 1996, later getting a series reboot on September 2017.